D12 A pharmacokinetic interaction between an angiotensin II receptor blocker (Valsartan) and a calcium channel blocker (Amlodipine)
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منابع مشابه
Calcium channel blocker overdose: Experience with amlodipine
Amlodipine overdose is only scarcely reported from India. We report two cases of near fatal Amlodipine overdose managed in our ICU with fluid, vasopressors, calcium infusion and Glucagon. Literature is reviewed and other treatment modalities discussed.
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Mebudipine is a new dihydropyridine calcium channel blocker, synthesized in our laboratory, for treatment of hypertension. It has shown a better efficacy than other drugs in this group. For assessing the risks of this drug, certain safety tests in the preclinical stage have been performed. In this study mutagenic effect of mebudipine was evaluated using Ames assay that could assess the mutageni...
متن کاملEvaluation of Mutagenicity of Mebudipine, a New Calcium Channel Blocker
Mebudipine is a new dihydropyridine calcium channel blocker, synthesized in our laboratory, for treatment of hypertension. It has shown a better efficacy than other drugs in this group. For assessing the risks of this drug, certain safety tests in the preclinical stage have been performed. In this study mutagenic effect of mebudipine was evaluated using Ames assay that could assess the mutageni...
متن کاملEffects of the angiotensin-1 receptor blocker valsartan compared with amlodipine on renal hemodynamics.
To the Editor: Delles et al investigated the effects of the angiotensin-1 (AT1) receptor blocker valsartan compared with those of the calcium antagonist amlodipine on renal hemodynamics and the renal microcirculation using inferences derived from Gomez’ formulas assessing renal hemodynamics. They concluded that at similar blood pressure (BP) control, valsartan maintained glomerular filtration r...
متن کاملAmlodipine and valsartan: calcium channel blockers/angiotensin II receptor blockers combination for hypertension
10.2217/14750708.4.1.31 © 20 Despite the availability of numerous antihypertensive agents, many patients with hypertension fail to achieve the blood pressure goals set out in current guidelines. These patients remain at a high risk of cardiovascular morbidity and mortality and require effective treatment options to reduce that risk. Current guidelines recognize that many patients require multip...
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ژورنال
عنوان ژورنال: American Journal of Hypertension
سال: 1997
ISSN: 0895-7061
DOI: 10.1016/s0895-7061(97)89040-1